Prospects for relevant glaucoma models with retinal ganglion cell damage in the rodent eye

Stem ‍Cells in Glaucoma Management

Glaucoma is the leading cause of preventable blindness worldwide. Despite tremendous advances in medical and surgical management of glaucoma in the recent years, the prevalence of glaucoma related blindness is anticipated to increase in the future decades because of the aging population. Stem cells have the potential to change the glaucoma management in several ways. There are several areas of ...

Understanding glaucomatous damage: Anatomical and functional data from ocular hypertensive rodent retinas

Glaucoma, the second most common cause of blindness, is characterized by a progressive loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field. Although the exact pathogenesis of glaucoma is not completely understood, a critical risk factor is the elevation, above normal values, of the intraocular pressure. Consequently, deciphering the anatomical and functio...

Experimental Glaucoma; Animal Models: Rodent P124 Neuroprotective Effect against the Axonal Damage-induced Retinal Ganglion Cell Death in the Apolipoprotein E Deficient Mice through the Suppression of Kainate Toxicity

Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve.

The 3 most common causes of visual impairment and legal blindness in developed countries (age-related macular degeneration, glaucoma, and diabetic retinopathy) share 1 end point: the loss of neural cells of the eye. Although recent treatment advances can slow down the progression of these conditions, many individuals still suffer irreversible loss of vision. Research is aimed at developing new ...

Changes in NMDA receptor contribution to synaptic transmission in the brain in a rat model of glaucoma

In the age-related, blinding disease glaucoma, retinal ganglion cells (RGCs) degenerate, possibly affecting glutamatergic retinofugal transmission to the brain. The superior colliculus (SC) is a major central target of retinofugal axons in the rodent, a much used disease model. We investigated the contribution of NMDA-type glutamate receptors to retinocollicular transmission in a rat glaucoma m...